Ovarian Biology

Our ovarian research team is studying causes of female infertility and factors in the ovary that enable the production of high quality oocytes. This can help us develop new tests and improve treatments for female infertility.

What Makes a Good Egg?

What Makes a Good Egg?

A good egg (oocyte) is essential for a successful pregnancy. Inside the ovaries, the egg grows within a follicle, which is a micro-environment that provides the egg with nutrients and other factors it needs to grow and mature. The quality of an egg can often be related to the environment it matured in. In this study, we look at the factors present in this micro-environment and how they affect egg quality.

Can Cell-Free DNA in Blood Be a Biomarker for Endometriosis

Endometriosis is when cells that line the uterus (endometrial cells) are also located outside the uterus, most commonly on other organs in the pelvis. This can cause abdominal pain and difficulty conceiving. While the presence of these symptoms may suggest endometriosis, the only way to confirm the diagnosis is through invasive surgery. In this study, we aim to identify whether non-invasive methods, such as factors in circulating blood, can be used instead of surgery, for diagnosing endometriosis.

Can Cell-Free DNA in Blood Be a Biomarker for Endometriosis
The Impact That Ovarian Stimulation and Trigger Protocols Have on the Supporting Cells of the Follicle

The Impact That Ovarian Stimulation and Trigger Protocols Have on the Supporting Cells of the Follicle

Inside the ovaries, the egg (oocyte) grows within a follicle. This follicle contains different types of cells which provide the micro-environment for the maturing egg. We are interested in understanding how the combinations and doses of different types of fertility drugs affect these supporting cells in subgroups of women undergoing IVF, and how this is linked to the quality/maturity of the eggs.